Multi-Omic Approach Associates Blood Methylome with Bronchodilator Drug Response in Pediatric Asthma: Summary statistics

We conducted an epigenome-wide association study of bronchodilator drug response (BDR) in a discovery and validation design. The discovery phase was focused on 221 African American children with asthma. The association between DNA methylation and BDR was conducted using the limma package correcting for age, sex, ancestry, and tissue heterogeneity. Summary statistics include the output from toptable limma function and CpG annotation (based on Illumina EPIC Manifest file v 1.0 B4) organized in the following columns:

Probe: Probe ID

Chr: chromosome

Pos: genomic position based on GRCh37/hg19

Gene: Gene annotation based on Illumina EPIC Manifest file v 1.0 B4

logFC: estimate of the log2-fold-change corresponding to the effect or contrast

SE: standard error

AveExpr: average log2-expression for the probe over all arrays and channels

t: moderated t-statistic

P.value: raw p-value

FDR: adjusted p-value by false discovery rate

B: log-odds that the gene is differentially expressed

Problem: Flagged potentially problematic probes