Development and in vitro Evaluation of Floating Mucoadhesive Tablet of Acebutolol Hydrochloride

In this study, it was intended to formulate floating Mucoadhesive tablets containing Acebutolol hydrochloride, an antihypertensive agent, to release the drug for a prolonged period of time in the upper part of the gastrointestinal tract in order to first-pass metabolism for improvement in bioavailability, to decrease the frequency of dosing, and to improve patient compliance. The effects of several polymers, including HPMC K4M and Carbopol 934, on the Mucoadhesive strength and release kinetics of floating Mucoadhesive tablets of Acebutolol hydrochloride were studied. The pre-compression blend of Acebutolol hydrochloride mucoadhesive tablets were characterized with respect to angle of repose, bulk density, tapped density, carr’s index and Hausner’s ratio and all the results indicated that the blend was having good flow property and hence better compression properties. The swelling studies were performed for the formulations and the results depicted that all the formulations have a good swelling index. The drug release studies depicted that the formulations release the drug in first order. So based on the results, formulation F3 was found to be an optimized formulation.