IGF-1 signaling

The activated IGF-1R (Insulin-like growth factor 1 receptor) regulates cellular adhesion, cytoskeletal organization and migration through interaction with adhesion molecules and integrin. In normal physiology the IGF-1R stimulates linear body growth, promotes neuronal survival and myelination, postnatal mammary gland development and lactation and is implicated in bone formation and renal function (Fortes et al,2013).

活化型IGF-1R（胰岛素样生长因子1受体）通过与其结合分子和整合素的相互作用，调节细胞粘附、细胞骨架组织和迁移。在正常生理过程中，IGF-1R刺激线性体格生长，促进神经元存活和髓鞘形成，促进出生后乳腺发育和泌乳，并涉及骨骼形成和肾脏功能（Fortes等，2013）。