The interest of inflammatory biomarkers in the diagnostic approach

Background: The role of inflammatory biomarkers in the etiological orientation is increasingly under study, and their potential significance is recognized.
Methods: Procalcitonin (PCT), neutrophil-lymphocyte ratio (NLR), C-reactive-protein (CRP), fibrinogen, ferritinaemia and lactate were measured on admission in all patients. The optimal cut-off values for the sensitivities and specificities to the infectious diseases were determined using the receiver operating curve(ROC) analysis and Youden's index. The diagnostic accuracy of biomarkers and their combinations for predicting infectious etiologies was calculated by area under the curve(AUC).
Results: A total of 164 patients were included in the study. The mean age was 50.7 ± 18 years [18 – 92 years]. Fifty-three patients (32.3%) were over 65 years old. Patients were split into four groups: 53 patients (32.3%) with infectious diseases of which 45 patients (84.9%) presented bacterial infections, 62 patients (37.8%) with inflammatory dis..., Procalcitonin (PCT), neutrophil-lymphocyte ratio (NLR), C-reactive-protein (CRP), fibrinogen, ferritinaemia and lactate were measured on admission in all patients. The optimal cut-off values for the sensitivities and specificities to the infectious diseases were determined using the receiver operating curve(ROC) analysis and Youden's index. The diagnostic accuracy of biomarkers and their combinations for predicting infectious etiologies was calculated by area under the curve(AUC)., , # The interest of inflammatory biomarkers in the diagnostic approach: A prospective cohort study

The role of inflammatory biomarkers in the etiological orientation is increasingly under study, and their potential significance is recognized. The role of inflammatory biomarkers in the etiological orientation is increasingly under study, and their potential significance is recognized. We conducted a prospective descriptive and analytical study about the etiological profile of inflammatory biomarkers measured on admission to distinguish infectious diseases, inflammatory diseases and neoplasia.

### Data collection:

The following data were collected from hospitalized patients: epidemiological details, history of comorbidities, clinical presentation, the final diagnosis, and inflammatory biomarkers. These biomarkers were as follows: white blood cells (WBC) (normal range: 4000-10000 cell/mm 3), neutrophils (normal range: 1500-7000 cells/mm3), lymphocytes (normal range:1500-4000 cells/mm3), N...