Levels of curcumin in plasma from chronic and acutely treated mice.

For mice treated chronically with a curcumin diet for 6 months, average free curcumin in plasma was 4.40±5.72 ng/mL and average free plus glucuronidated curcumin was 12.52±10.68 ng/mL, indicating that 94.1±7.3% of curcumin was glucuronidated. For mice treated acutely with 15 mg/kg/day curcumin i.p. for 15 days and sacrificed 5 hours after the final treatment, average free curcumin was 11.55±2.51 ng/mL and average free plus glucuronidated curcumin was 372.89±104.24 ng/mL, indicating that 96.6±1.5% of curcumin was glucuronidated (samples from individual mice were run in triplicate; mean ± SD; ND, not detectable; NA, not applicable).Levels of curcumin in plasma from chronic and acutely treated mice.