ATF4 regulates MYB to increase g-globin in response to loss of Ã-globin [RNA-seq]
收藏NIAID Data Ecosystem2026-03-12 收录
下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP269941
下载链接
链接失效反馈官方服务：
资源简介：
Boontanrart et al model the cellular stress that occurs upon reduction in Ã-globin in human erythroid cells. Decrease in Ã-globin attenuates the eIF2aP-ATF4 pathway and results in upregulating fetal g-globin. Down-regulation of ATF4 leads to decreased levels of the g-globin repressor MYB through direct binding at the HBS1L-MYB intergenic region. Overall design: RNA-seq of WT and HBBko HUDEP-2 cells
创建时间：
2020-10-27
