Dataset related to the article "Stereotactic radioablation for the treatment of ventricular tachycardia: preliminary data and insights from the STRA-MI-VT phase Ib/II study"

This record contains raw data related to the article "Stereotactic radioablation for the treatment of ventricular tachycardia: preliminary data and insights from the STRA-MI-VT phase Ib/II study" Abstract<br> Purpose We present the preliminary results of the STRA-MI-VT Study (NCT04066517), a spontaneous, phase Ib/II study,<br> designed to prospectively test the safety and efficacy of stereotactic body radiotherapy (SBRT) in patients (pts) with advanced<br> cardiac disease and intractable ventricular tachycardia (VT).<br> Methods Cardiac computed tomography (CT) integrated by electroanatomical mapping was used for substrate identification<br> and merged with dedicated CT scans for treatment plan preparation. A single 25-Gy radioablation dose was delivered<br> by a LINAC-based volumetric modulated arc therapy technique in a non-invasive matter. The primary safety endpoint was<br> treatment-related adverse effects during acute and long-term follow-up (FU), obtained by regular in-hospital controls and<br> implantable cardioverter defibrillator (ICD) remote monitoring. The primary efficacy endpoint was the reduction at 3 and<br> 6 months of VT episodes and ICD shocks.<br> Results Seven out of eight patients (men; age, 70 ± 7 years; ejection fraction, 27 ± 11%; 3 ischemic, 4 non-ischemic cardiomyopathies)<br> underwent SBRT. At a median 8-month FU, no treatment-related serious adverse event occurred. Three patients<br> died from non-SBRT-related causes. Four patients completed the 6-month FU: the number of VT decreased from 29 ± 33<br> to 11 ± 9 (p = .05) and 2 ± 2 (p = .08), at 3 and 6 months, respectively; shocks decreased from 11 to 0 and 2, respectively.<br> At 6 months, all pts. showed a significant reduction of VT episodes and no electrical storm recurrence, with the complete<br> regression of iterative VTs in 2/2 pts.<br> Conclusion The STRA-MI-VT Study suggests that SBRT can be considered an alternative option for the treatment of VT in<br> patients with structural heart disease and highlights the need for further clinical investigation addressing safety and efficacy. <br> Keywords Ventricular tachycardia/ventricular arrhythmias · Stereotactic body radiotherapy/radioablation · Catheter<br> ablation · Structural heart disease/dilated cardiomyopathy · Multimodal imaging