Lewis Acid-Catalyzed Nucleophilic Addition of Indoles to in Situ-Generated 2‑Amidoallyl Cations
收藏NIAID Data Ecosystem2026-03-10 收录
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We report herein the first Lewis acid-catalyzed generation of 2-amidoallyl cations through ring-opening of 4-benzylidene-2-oxazolines with Sc(OTf)3. Upon nucleophilic addition of indoles, indolylenamides were obtained with yields of 60–99% and excellent (Z)-selectivity. In addition, the novel strategy was also successfully applied to pyrroles and naphthols as π-nucleophiles. A Brønsted acid-catalyzed process using TfOH formed in situ was ruled out by control experiments.
创建时间：
2017-05-22
