SPAD-targeted integration by phenotypically mixed WT/N74D CA viruses.

HIV-1 integration sites were determined in 293T cells infected with viruses containing the indicated proportions of WT CA incorporated into N74D CA viruses. 0% WT/CA indicates a virus with 100% N74D/CA. Statistical analysis, P values were calculated by Fisher’s exact test in the indicated pairwise manner. The random integration control (RIC) was calculated in silico. The % of integration sites in SPADs for each sample is shown to the right. Note: P values from the row corresponding to 100% WT/CA and the column corresponding to 0% WT/CA were used in S8B Fig to show statistical significance vs WT (black) and vs N74D (red) viral integration sites, respectively. (XLSX)