Crystal Structure of WDR5 in complex with Triazole-Based Inhibitors

Crystal Structure of WDR5 in complex with Triazole-Based Inhibitors Descriptor: (6P)-6-[1-ethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3-[(4-fluoro-3-methylphenyl)methyl]-8-[(2-methyl-1H-imidazol-1-yl)methyl]-4,5-dihydro-3H-naphtho[1,2-d][1,2,3]triazole, WD repeat-containing protein 5 Authors: Goins, C.M, Stauffer, S.R. Deposit date: 2025-02-17 Release date: 2025-08-13 Last modified: 2026-07-08 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Development and characterization of triazole-based WDR5 inhibitors for the treatment of glioblastoma. JCI Insight, 11, 2026