Data for: Kilohertz Transcranial Magnetic Perturbation (kTMP): A new non-invasive method to modulate cortical excitability

Non-invasive brain stimulation (NIBS) provides a method for safely perturbing brain activity and has been employed in basic research to test hypotheses concerning brain-behavior relationships with increasing translational applications. We introduce and evaluate a novel subthreshold NIBS method: kilohertz transcranial magnetic perturbation (kTMP). kTMP is a magnetic induction method that delivers continuous kHz-frequency cortical electric fields (E-fields) which may be amplitude-modulated to potentially mimic electrical activity at endogenous frequencies. We used TMS to compare the amplitude of motor-evoked potentials (MEPs) in a hand muscle before and after kTMP. In Experiment 1, we applied kTMP for 10 min over the motor cortex to induce an E-field amplitude of approximately 2.0 V/m, comparing the effects of waveforms at frequencies of 2.0, 3.5, or 5.0 kHz. In Experiments 2 and 3, we used two forms of amplitude-modulated kTMP with a carrier frequency at 3.5 kHz and modulation frequencie..., , , # Data for: Kilohertz Transcranial Magnetic Perturbation (kTMP): A new non-invasive method to modulate cortical excitability

Dataset DOI: [10.5061/dryad.qz612jmsh](10.5061/dryad.qz612jmsh)

## Description of the data and file structure

**Apparatus**

The **kilohertz transcranial magnetic perturbation (kTMP)** system consists of a high-amplitude current source, a TMS coil, and a control system. The same TMS coil may be connected to either the kTMP current source or to a commercial TMS pulse generator (MagVenture MagPro R30 with MagOption), permitting interleaved kTMP-TMS experiments and ensuring identical kTMP and TMS E-field distributions up to an amplitude scaling factor. The kTMP amplifier (AE Techron Model 7794) is a voltage-controlled current source capable of delivering up to 200 A to the coil. We used an actively-liquid-cooled figure-of-eight coil (MagVenture Cool-B65; inner and outer loop diameters of 35 mm and 75 mm, respectively).

The kTMP control system consists of a person..., Participant data is coded as P01, P02 etc, no identifying information is contained within the datasets.