CNIH1 binds TFGA and AREG precursors

CNIH1, also known as ERV14, is a member of the ERV family of proteins that act as cargo receptors for ER-to-ERGIC trafficking (reviewed in Dancourt and Barlowe, 2010). CNIH1 preferentially interacts with transmembrane proteins like the precursor forms of TFGA and AREG, and mediates their packaging into COPII vesicles by interacting with components of the COPII coat (Castro et al, 2007).

CNIH1，亦称ERV14，是ERV蛋白家族的成员，该家族蛋白作为ER至ERGIC运输的货物受体（参见Dancourt和Barlowe，2010年的综述）。CNIH1优先与跨膜蛋白如TFGA和AREG的前体形式相互作用，并通过与COPII衣被成分的相互作用，介导其包装进入COPII囊泡（Castro等，2007年）。