Non-Hemolytic and Non-Toxic AMPs from Cephalopods' Posterior Salivary Glands: Singular Set and Sets with Similarity to Characterised AMPs

The datasets presented here are the result of a comprehensive comparison involving 68,694 non-hemolytic and non-toxic Antimicrobial Peptides (AMPs) extracted from the posterior salivary glands of Cephalopods (doi: 10.17632/htntmccyd4.1). The comparison was made against characterized AMPs registered in the StarPep database (http://mobiosd-hub.com/starpep/)

Dataset Structure:
The provided datasets, available in FASTA file format, are structured as follows:
1. Singular NoHemNoTox AMPs (5,466): AMPs from cephalopods that are non-hemolytic and non-toxic, exhibiting less than 40% sequence identity with members in the StarPep database.
2. NoHemNoTox AMPs_SimHigher40 (63,228): AMPs from cephalopods that are non-hemolytic and non-toxic, sharing more than 40% sequence identity with members in the StarPep database.
3. NoHemNoTox AMPs_Sim40-50 (26,744): AMPs from cephalopods that are non-hemolytic and non-toxic, sharing 40-50% sequence identity with members in the StarPep database.
4. NoHemNoTox AMPs_Sim50-60 (30,217): AMPs from cephalopods that are non-hemolytic and non-toxic, sharing 50-60% sequence identity with members in the StarPep database.
5. NoHemNoTox AMPs_Sim60-70 (5,716): AMPs from cephalopods that are non-hemolytic and non-toxic, sharing 60-70% sequence identity with members in the StarPep database.
6. NoHemNoTox AMPs_Sim70-80 (453): AMPs from cephalopods that are non-hemolytic and non-toxic, sharing 70-80% sequence identity with members in the StarPep database.
7. NoHemNoTox AMPs_SimHigher80 (98): AMPs from cephalopods that are non-hemolytic and non-toxic, sharing more than 80% sequence identity with members in the StarPep database.

These datasets provide a valuable resource for screening purposes as part of the peptide drugs discovery, especially considering their similarities to the known chemical space (characterized AMPs in the StarPep database).