Multivalent Activation in Temporary Phosphate Tethers: A New Tether for Small Molecule Synthesis

A new tether for small molecule synthesis is reported. This functionally active tether mediates the desymmetrization of a pseudo-C2-symmetric
tris-allylic phosphate triester to generate a P-chiral bicyclo[4.3.1]phosphate containing ample steric and stereoelectronic differentiation for
investigating chemo-, regio-, and stereoselective transformations. Overall, the method reported herein demonstrates a fundamentally new role
of phosphates in synthesis and provides differentiated polyol building blocks for use in natural product synthesis.