Data_Sheet_1_Cardiovascular Biomarkers for Prediction of in-hospital and 1-Year Post-discharge Mortality in Patients With COVID-19 Pneumonia.docx

AimsWhile COVID-19 affects the cardiovascular system, the potential clinical impact of cardiovascular biomarkers on predicting outcomes in COVID-19 patients is still unknown. Therefore, to investigate this issue we analyzed the prognostic potential of cardiac biomarkers on in-hospital and long-term post-discharge mortality of patients with COVID-19 pneumonia.MethodsSerum soluble ST2, VCAM-1, and hs-TnI were evaluated upon admission in 280 consecutive patients hospitalized with COVID-19-associated pneumonia in a single, tertiary care center. Patient clinical and laboratory characteristics and the concentration of biomarkers were correlated with in-hospital [Hospital stay: 11 days (10; 14)] and post-discharge all-cause mortality at 1 year follow-up [FU: 354 days (342; 361)].Results11 patients died while hospitalized for COVID-19 (3.9%), and 11 patients died during the 1-year post-discharge follow-up period (n = 11, 4.1%). Using multivariate analysis, VCAM-1 was shown to predict mortality during the hospital period (HR 1.081, CI 95% 1.035;1.129, p = 0.017), but not ST2 or hs-TnI. In contrast, during one-year FU post hospital discharge, ST2 (HR 1.006, 95% CI 1.002;1.009, p < 0.001) and hs-TnI (HR 1.362, 95% CI 1.050;1.766, p = 0.024) predicted mortality, although not VCAM-1.ConclusionIn patients hospitalized with Covid-19 pneumonia, elevated levels of VCAM-1 at admission were associated with in-hospital mortality, while ST2 and hs-TnI might predict post-discharge mortality in long term follow-up.

本研究旨在探讨心血管系统受COVID-19影响的同时，心血管生物标志物对预测COVID-19患者预后可能产生的临床影响尚不明确。为此，本研究分析了心脏生物标志物对COVID-19肺炎患者在院期间及长期出院后死亡率的预测潜能。研究方法：在一家单一的三级医疗中心，对280名连续住院的COVID-19相关肺炎患者进行了入院时的血清可溶性ST2、VCAM-1和hs-TnI水平评估。将患者的临床和实验室特征与入院期间的住院时间[住院时间：11天（10；14）]和1年随访期内的全因死亡率[随访：354天（342；361）]进行相关性分析。研究结果：11名患者在住院期间死于COVID-19（3.9%），11名患者在1年的出院后随访期间死亡（n = 11，4.1%）。多因素分析表明，VCAM-1可预测住院期间的死亡率（HR 1.081，95% CI 1.035；1.129，p = 0.017），但ST2或hs-TnI则不然。相反，在出院后一年的随访期间，ST2（HR 1.006，95% CI 1.002；1.009，p < 0.001）和hs-TnI（HR 1.362，95% CI 1.050；1.766，p = 0.024）可预测死亡率，尽管VCAM-1则不然。结论：在住院的COVID-19肺炎患者中，入院时VCAM-1水平升高与住院期间死亡率相关，而ST2和hs-TnI可能预测长期随访期间的出院后死亡率。