Immune profiling of different human tumors coupled with murine reverse translational studies identify CD73 as a rational combinatorial target for GBM

To characterize the heterogenous immune infiltrate across five tumor types (GBM, prostate cancer, CRC, RCC, and NSCLC) in human patients prior to any immunotherapy, and then utilize knowledge about the distinct phenotypes found in various tumor types to rationally design a reverse translational experiment in a murine model.