Discrimination and calibration of Framingham functions (FRS), recalibrated FRS and Health ABC function in men (n = 981).

Abbreviations: FRS: Framingham risk score; CHD: coronary heart disease; coef: coefficient; CI: confidence interval; SD: standard deviation; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol.*Some of the Framingham risk factors categories were collapsed to avoid cells with limited numbers of events and /or unpredictive trends. The proportionality assumption was tested using the Therneau and Grambsch statistics, which is based on the Schoenfeld residuals. The assumption was accepted (p = 0.33).†Based on Wilson et al. [2].‡Cholesterol categories proposed by the National Cholesterol Education Program [24].∥Blood pressure categories: Optimal (Systolic80); Normal (Systolic85); High normal (Systolic90); Stage I (Systolic[24].¶Estimated from the Framingham adjusted survival rate (survival rate at the mean value of the risk factors) at 10 years: S0(10) = 90015 [2], as: Ŝ0(7.5) = S0(10)0.75 = 0.9241 (exponential model).#Kaplan-Meier survival function at t = 7.5 years on HABC data, similar to reference [24].**Adjusted survival rate at t = 7.5 years obtained on the HABC cohort as the baseline survival functions of the multivariate Cox model, similar to reference [9].††After bootstrap correction for the optimism (1000 bootstrap samples from the original dataset [20]), c-index = 0.580 (p = 0.90 for comparison with Framingham function).∥ ∥Adaptation to the Cox model of the Hosmer-Lemeshow test of goodness of fit [33], comparing observed and expected failures within deciles of predicted risk. Larger p values indicate better calibration [21].