CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560

CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560 Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y. Deposit date: 2022-06-17 Release date: 2022-11-02 Last modified: 2025-06-18 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560. Nat Commun, 13, 2022