SIGNOR

SIGNOR (信号网络开放资源)是一个存储生物实体间实验验证的因果关系的数据库，专注于信号转导通路。它以“活动流”模型表示调控信息，每个关系都注释有效应（上调/下调）和机制（如结合、磷酸化）。SIGNOR 3.0包含近2.3万条手动注释的因果互作，涉及蛋白质、化学物质、复合物等。

SIGNOR (Open Resource for Signaling Networks) is a database that stores experimentally validated causal relationships between biological entities, focusing on signal transduction pathways. It represents regulatory information via an "activity flow" model, where each relationship is annotated with its regulatory effect (upregulation or downregulation) and underlying mechanism (e.g., binding, phosphorylation, etc.). SIGNOR 3.0 contains nearly 23,000 manually curated causal interactions involving proteins, chemical substances, molecular complexes, and other related biological components.

搜集汇总

背景与挑战

背景概述

SIGNOR是一个信号转导网络数据库，收录了实验验证的分子互作信息，特别是信号通路中的关键事件。数据来源于人工策展的PubMed文献，涵盖人类及其他物种的多种生理和病理过程信号通路。