Dysregulated Fatty Acid Metabolism Following Intermittent Hypoxemia-induced Neonatal Brain Injury is Rescued by Treatment with Acetate

Targeted lipidomics of frozen mouse microdissected hippocampal tissue. Using an established model of neonatal brain injury due to intermittent hypoxemia, we examined the extent of changes in the brain’s lipid profile. Mice underwent intermittent hypoxemia (IHx) during postnatal days (P) 1-11 and were compared to normoxia controls (Nx). We measured hippocampal lipids at several time points (P11, P17, P22, and P30). Our results show changes in hippocampal lipid composition.