Database Of Local Biomolecular Conformers

Dolbico, the Database Of Local Biomolecular Conformers, stores DNA structural data including the information about DNA local spatial arrangement. The main aim of Dolbico is the exploration of DNA structure at a local level. The analysis of local DNA structure is based on a classification system that uses 9 torsional angles (7 backbone angles and two glycosidic torsions) to categorize dinucleotides into several distinct conformational families. The implemented classification workflow is able not only to classify dinucleotides into already existing classes, but is also able to discover new classes in new solved DNA structures.

局部生物分子构象数据库（Database Of Local Biomolecular Conformers，简称Dolbico）存储DNA结构数据，涵盖DNA局部空间排布相关信息。该数据库的核心目标为开展DNA局部结构的探索研究。局部DNA结构的分析基于一套分类体系，该体系通过9个扭转角（torsional angles）——其中7个为主链扭转角（backbone angles）、2个为糖苷键扭转角（glycosidic torsions）——将二核苷酸（dinucleotides）划分为多个不同的构象家族。该已实现的分类流程不仅可将二核苷酸归入现有类别，还能在新解析的DNA结构中发现全新的构象类别。

搜集汇总

背景与挑战

背景概述

Dolbico是一个存储DNA局部空间排列结构数据的数据库，旨在探索局部DNA结构，并基于扭转角对二核苷酸进行分类。该数据库包含10,657个DNA结构和319,536个二核苷酸，提供搜索和浏览功能以支持结构分析。