Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections

The report contains data on protein levels obtained from dried blood spot (DBS) samples.The DBS originated from donors who provided self-sampling blood using a sampling kit (Capitainer AB). The studies were conducted in the general population in Stockholm and Gothenburg (Sweden) during the COVID-19 pandemic in the spring of 2020 and 2021:Levels of circulating antibodies were determined in the 2021 study by multi-analyte serology using the Luminex platform. Serology data from the 2020 studies have been deposited in a previous submission. All data sets have been processed and normalized using a linear model described in the publication of the previous submission.Levels of circulating proteins were determined by proximity extension assays using three Target96 panels from the Olink platform. The raw NPX data has been processed using AbsPQN, as described in the manuscript related to this submission.Other data is provided in the manuscript.Access to this individual-level human data can be granted for non-commercial validation purposes and upon reasonable request to the provided contact. A reasonable request should contain the following:Name of PI and host organizationContact detailsThe scientific purpose of the data access requestCommitment to inform when the data has been used in a publicationCommitment not to host or share the data outside the requesting organizationStatement of non-commercial use of data

本报告收录了从干燥血斑（DBS）样本中获取的蛋白质水平数据。该DBS源自提供自采样血液的捐赠者，他们使用Capitainer AB提供的采样套装进行采样。研究于2020年和2021年春在瑞典斯德哥尔摩和哥德堡（瑞典）的普通人群中开展，正值COVID-19大流行期间：2021年的研究通过Luminex平台的多分析血清学方法确定了循环抗体的水平。2020年的血清学数据已在前一次提交中存档。所有数据集均已通过前一次提交中发表的线性模型进行处理和归一化。循环蛋白质的水平是通过Olink平台的三个Target96面板进行邻近延伸分析确定的。原始NPX数据已根据与本次提交相关的手稿中所述的AbsPQN进行处理。其他数据已在手稿中提供。对于非商业验证目的，并经合理请求后，可提供对个体级别的人类数据的访问权限。合理的请求应包含以下内容：PI姓名及其所属机构联系方式数据访问请求的科学目的承诺在出版物中使用数据时进行通知承诺不将数据托管或分享至请求机构之外声明数据非商业用途。