Association between Gene Polymorphisms and Risk of ≥25% Decline in GFR Over 11 Years, Adjusted for Age.

AGT, Angiotensinogen; reference = M/M (dose response and dominant models) or M/M+M/T (recessive model).AGT, Angiotensinogen; reference = A/A (dose response and dominant models) or A/A+A/C (recessive model).ACE, Angiotensin Converting Enzyme; reference = I/I (dose response and dominant models) or I/I+I/D (recessive model).AT1R, Angiotensin II Type 1 Receptor; reference = A/A (dose response and dominant models) or A/A+A/C (recessive model).AS, Aldosterone Synthase; reference = T/T (dose response and dominant models) or T/T+T/C (recessive model).Adducin G460W; reference = G/G (dose response and dominant models) or G/G+G/W (recessive model).APOE, Apolipoprotein A; reference = APOE Summary Score 0; Summary Score system respectively assigns +1, 0, or −1 per E2, E3, or E4 allele of an individual with genotypes (and scores) of: E2/E2 (+2), E2/E3 (+1), E2/E4 (0), E3/E3 (0), E3/E4 (−1), E4/E4 (−2).