Disruption of neonatal Purkinje cell function underlies injury-related learning deficits

This folder contains data related to the paper:

Disruption of neonatal Purkinje cell function underlies injury-related learning deficits

Aaron Sathyanesan1*, Panagiotis Kratimenos1,2,3, and Vittorio Gallo1,3*
1 Center for Neuroscience Research and 2 Division of Neonatology, Children’s National Research Institute, Children’s National Hospital, Washington DC
3 George Washington University School of Medicine and Health Sciences, Washington DC
* Co-corresponding authorship
Email:  [e-mail] (Vittorio Gallo)
[e-mail] (Aaron Sathyanesan)

Description of files:
'Figure1.mat' - Contains data related to representative fiber photometry trace in Figure 1D
        't' - total time of recording (in seconds)
        'dFF_480' - GCaMP6f dFF trace
        'dFF_405' - Isosbestic control trace
        'USonly', 'CSonly', 'Paired', and 'trials' - categorized time-marked events

'Figure2_and_SIAppendix_FiguresS4-S6.mat' - Contains data related to Figure 2A-D, and SI Appendix Figures S4-S6
        'FP_1' - structural array containing relevant data
            'FP_1.condition' - 'Nx' or 'Hx' (Figure 2C-D)
            'FP_1.day' - learning session 1, 2, or 3 (Figure 2C-D)
            'FP_1.zCSUS' - mean z-score dF/F in CS-US window for paired learning trials (Figure 2G)
            'FP_1.zdFF' - all z-score dF/F traces (Figure 2C-D)
            'FP_1.CSUS_t' - time vector with t = 0 as C.S. onset (Figure 2C-D)
            'FP_1.rep_cond' - 'Nx' or 'Hx' for representative data (Figure 2A-B)
            'FP_1.rep_day' - learning session 1, 2, or 3 (Figure 2A-B)
            'FP_1.rep_dFF' - normalized GCaMP6f dF/F for (Figure 2A-B)
            'FP_1.trialduration' - trial durations for all trials (SI Appendix Figure S4)
            'FP_1.missteptime' - missteptime for all trials (SI Appendix Figure S5)
            'FP_1.velocity' - velocity for all trials (SI Appendix Figure S6)
            'FP_1.shortsteptime' - short steptime for trials (SI Appendix Figure S4)
            'FP_1.shortmissteptime' - short missteptime for all trials (SI Appendix Figure S5)
            'FP_1.longsteptime' - long steptime for trials (SI Appendix Figure S4)
            'FP_1.longmissteptime' - long missteptime for all trials (SI Appendix Figure S5)
            'FP_1.zPost' - z-scored post-perturbation steptime (Figure 2G)

'Figure3.mat' - Contains data related to Figure 3C
        'FP_2' - structural array containing relevant data
            'FP_2.condition' - 'saline' or 'CNO'
            'FP_2.day' - learning session 1, 2, or 3
            'FP_2.zdFF_DRD' - all z-score dF/F traces
            'FP_2.CSUS_tmod' - time vector with t = 0 as C.S. onset

'SIAppendix_FigureS2.mat' - Contains data related to SI Appendix Figure S2b-c
        'Nx' - structural array containing relevant data to Nx animal
        'Hx' - structural array containing relevant data to Hx animal    
        In both Nx and Hx:
            'trial_rep' - representative trial event mark
            't_rep' - time
            'air_rep' - air onset event mark
            'dFF_480_rep' - GCaMP6f dF/F signal

'SIAppendix_FigureS3.mat' - Contains data related to SI Appendix Figure S3a and d
        'FP_US' - structural array containing relevant data to US-only trials
            'FP_US.condition_US' - 'Nx' or 'Hx'
            'FP_US.zUStrialsonly - z dF/F traces in US only trials
            'FP_US.CSUS_tmod - time with respect to t = 0 as U.S. onset
        'FP_CS' - structural array containing relevant data to CS-only trials
            'FP_CS.condition_CS' - 'Nx' or 'Hx'
            'FP_CS.zCStrialsonly - z dF/F traces in CS only trials
            'FP_CS.CSUS_tmod - time with respect to t = 0 as C.S. onset

'Figure 2E data.pdf' - Contains data related to Figure 2E

'Figure 2F data.pdf' - Contains data related to Figure 2F

'Figure 2H data.pdf' - Contains data related to Figure 2H

'Figure 3D data.pdf' - Contains data related to Figure 3D

'SIAppendix Figure S3 data.pdf' - Contains data related to SI Appendix Figure S3

'SIAppendix Figure S7 data.pdf' - Contains data related to SI Appendix Figure S7

'SIAppendix Figure S8 data.pdf' - Contains data related to SI Appendix Figure S8

'SIAppendix Figure S9 data.pdf' - Contains data related to SI Appendix Figure S9