Genome-wide occupancies of multiple transcription activators in PDLSCs induced by GIPRA

Our previous study (Environ Pollut. 2023;323:121307) has indicated that Glucose-dependent insulinotropic polypeptide receptor (GIPR) is down-regulated in periodontal ligament stem cells (PDLSCs) by cigarette and E-cig. In the current study, ChIP-seq was conducted to study the genome-wide occupancies of phosphorylated CREB (p-CREB), p-STAT, p-ERK and TCF4 in PDLSCs treated with GIPR agonist (GIPRA) (Pro3) GIP (0.5 nM, 24 h, Cat. No. HY-P3584, MCE, China) and ERK1/2 inhibitor SCH772984 (0.5 µM, 24 h, HY-50846, MCE) compared to normal PDLSCs.