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Transcription profiling of human leukemia cell lines reveals Myc inhibits p27-induced erythroid differentiation

ChEBI2009-01-10 更新2026-07-21 收录

白血病细胞分化

Myc-p27信号通路

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MEXP-1772 数据链接链接失效反馈

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Transcription profiling of human leukemia cell lines reveals Myc inhibits p27-induced erythroid differentiation

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创建时间：

2009-01-10

白血病细胞分化

HDAC抑制剂

Altered expression and activity of histone deacetylases (HDACs) have been correlated with tumorigenesis. Inhibitors of HDACs (HDACi) induce acetylation of histone and non-histone proteins affecting ge

DataCite Commons2020-09-04 更新70

Long Intergenic Non-Coding RNA HOTAIRM1 Regulates Cell Cycle Progression During Myeloid Maturation in NB4 Promyelocytic Leukemia Cells

白血病细胞分化

非编码RNA调控

HOTAIRM1 is a long intergenic non-coding RNA located in the human HOXA gene cluster, with gene expression highly specific for maturing myeloid cells, particularly during all-trans retinoic acid (ATRA)

NIAID Data Ecosystem40

Reprogramming leukemic cells to terminal differentiation by inhibiting specific cyclin-dependent kinases in G(1)

白血病细胞分化

细胞周期蛋白依赖性激酶抑制

Some tumor cells can be stimulated to differentiate and undergo terminal cell division and loss of tumorigenicity. The in vitro differentiation of murine erythroleukemia (MEL) cells is a dramatic exam

PubMed Central2000-12-12 更新30

mRNA profiles of CD43++c-kit+, CD43+c-kit- and CD43-c-Kit- AML1-ETO9a murine leukemic bone marrow cells

白血病细胞分化

转录组分析

We discovered a spontaneous differentiation path characterized by CD43 and c-Kit in the AE9a murine model, where the leukemia-initiating potential is lost while leukemic cells display features of eryt

NIAID Data Ecosystem50

Gene Expression-Based High Throughput Screening: Primary Patient AML Blasts, Normal Neutrophils, and Normal Monocytes

白血病细胞分化

化学基因组学

We developed a general approach to small molecule library screeening called GE-HTS (Gene Expression-Based High Throughput Screening) in which a gene expression signature is used as a surrogate for cel

NIAID Data Ecosystem30

Transcription profiling of human leukemia cell lines reveals Myc inhibits p27-induced erythroid differentiation

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