Crystal Structure of SARS-CoV-2 Main Protease (Mpro) H172Y Mutant in Complex with Inhibitor GC376
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Crystal Structure of SARS-CoV-2 Main Protease (Mpro) H172Y Mutant in Complex with Inhibitor GC376 Descriptor: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 Authors: Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y. Deposit date: 2022-06-02 Release date: 2022-07-13 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir. Biorxiv, 2022
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2022-06-02
