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Proline-Catalyzed Asymmetric Synthesis of <i>syn</i>- and <i>anti</i>-1,3-Diamines

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NIAID Data Ecosystem2026-03-08 收录
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A general organocatalytic strategy for asymmetric synthesis of both syn/anti-1,3-diamines has been developed. The strategy employs proline-catalyzed sequential α-amination and Horner–Wadsworth–Emmons (HWE) olefination of aldehydes as the key step where syn-1,3-diamine was obtained as the most favorable product.

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2013-12-06
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