Lineage-specific selection and the evolution of virulence in Candida albicans. Lineage-specific selection and the evolution of virulence in Candida albicans

This data was generated to compare genome-wide expression differences between a major fungal pathogen of humans, Candida albicans and its less pathogenic relative, Candida dubliniensis, using interspecies hybrids to systematically identify cis-regulatory adaptations. Overall design: RNA-Seq data generated in this study for allele-specific expression experiments and overexpression experiments. Samples were grown in culture media (planktonic) to mid-log phase and RNA was extracted using the Ambion RiboPure RNA Purification Kit for Yeast. Every experiment was performed in duplicate (represented by A and B appended to the file names). For the Experiments in the hybrid organism (ASE), the experiments are internally controlled without need for an external control. For the overexpression RNA-Seq experiments, the controls are the Empty vector samples.