Beta Amyloid toxicity in a Caenorhabditis elegans model of Alzheimer's disease
收藏Alliance of Genome Resources2026-08-01 收录
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Transgenic animals were engineered to express human amyloid peptide controlled by a muscle-specific, heat-inducible promoter. At low temperatures (16C) Abeta expression is minimal, while at higher temperatures (20-25C) Abeta accummulates in large quantities and causes paralysis. GFP- and GFP::degron (a toxic aggregating GFP mutant)-expressing animals were used as controls.
