<i>In vivo/In silico</i> - anticancer potential of <i>Mangifera indica</i> Linn seed kernel phenolic extract against Ehrlich ascites induced carcinoma in Swiss albino mice

Cancer is a disease marked by the uncontrolled growth and replication of cells. This study investigates the anticancer effects of the phenolic extract from <i>Mangifera indica</i> (MISKPE) seed kernels on Ehrlich ascites carcinoma in Swiss albino mice. The findings highlight the therapeutic potential of MISKPE, as it reduced body weight and increased the lifespan of the mice. <i>In vivo</i> antioxidant assays showed significant improvements, including 4.47% SOD, 0.71% LPO and 22.35% catalase activity, alongside enhanced hematological parameters. Phytochemical analysis using 13 C and 1H NMR, as well as GC-MS, identified bioactive compounds like mangiferin, benzene-1, 3, 5-triol and 46-cholestadien-3-beta-ol. Additionally, in silico docking studies suggest that mangiferin, a major component of MISKPE, may possess strong anticancer properties.癌症是一类以细胞不受控增殖与复制为核心特征的疾病。本研究探讨了*Mangifera indica*（杧果）种仁酚类提取物（MISKPE）对瑞士白化小鼠艾氏腹水癌的抗癌作用。研究结果凸显了MISKPE的治疗潜力：其可降低小鼠体重并延长其生存期。*In vivo*（体内）抗氧化实验显示多项指标得到显著改善：超氧化物歧化酶（SOD）活性提升4.47%、脂质过氧化物（LPO）水平降低0.71%、过氧化氢酶活性提升22.35%，同时血液学参数也得到优化。采用碳-13核磁共振（¹³C NMR）、氢-1核磁共振（¹H NMR）及气相色谱-质谱联用（GC-MS）进行的植物化学分析，鉴定出芒果苷、苯-1,3,5-三醇、4,6-胆甾二烯-3β-醇等多种生物活性成分。此外，*In silico*（计算机模拟）分子对接实验表明，作为MISKPE主要成分的芒果苷可能具备较强的抗癌活性。

搜集汇总

背景与挑战

背景概述

该数据集主要研究芒果（Mangifera indica）种子酚类提取物（MISKPE）对艾氏腹水癌小鼠模型的抗癌潜力。研究结合体内实验和计算机模拟方法，发现MISKPE能显著改善小鼠的抗氧化指标和血液学参数，并鉴定出芒果苷等关键生物活性成分，表明其具有潜在的抗癌特性。数据集包含补充文件，支持生物化学、药理学和癌症研究领域的相关分析。