MicroRNA-21 Regulates PI3K/Akt/mTOR Signaling by Targeting TGFβI during Skeletal Muscle Development in Pigs
收藏Figshare2016-01-15 更新2026-04-29 收录
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https://figshare.com/articles/dataset/_MicroRNA_21_Regulates_PI3K_Akt_mTOR_Signaling_by_Targeting_TGF_946_I_during_Skeletal_Muscle_Development_in_Pigs_/1407480
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MicroRNAs (miRNAs), which are short (22–24 base pairs), non-coding RNAs, play critical roles in myogenesis. Using Solexa deep sequencing, we detected the expression levels of 229 and 209 miRNAs in swine skeletal muscle at 90 days post-coitus (E90) and 100 days postnatal (D100), respectively. A total of 138 miRNAs were up-regulated on E90, and 31 were up-regulated on D100. Of these, 9 miRNAs were selected for the validation of the small RNA libraries by quantitative RT-PCR (RT-qPCR). We found that miRNA-21 was down-regulated by 17-fold on D100 (P
创建时间：
2016-01-15
