Prolonged water-only fasting followed by a whole-plant-food diet is a potential long-term management strategy for hyper-tension and obesity

Objective: This single-arm, pre–post interventional trial (clinicaltrials.gov, NCT04515095) investigates the safety, feasibility, and potential effectiveness of prolonged water-only fasting followed by a whole-plant-food diet in the long-term management of hypertension and other cardiometabolic disorders. Methods: Safety was assessed based on adverse events (AEs) that were recorded according to Common Terminology Criteria for Adverse Events (CTCAE) v5.0. Feasibility was assessed based on retention rate, ability to complete minimal fast length, and intervention acceptability. Twenty-nine participants with stage 1 and 2 hypertension and without type 2 diabetes were enrolled from a residential fasting center. Results: Study retention was 100% at the end of the refeed and 93% at the six-week follow-up visit. Median (range) fasting and refeeding duration were 11 (7–40) and 5 (3–17) days, respectively, and 90% of participants were able to complete at least 7 days of fasting. The majority of A..., , , # Prolonged Water-Only Fasting Followed by a Whole-Plant-Food Diet Is a Potential Long-Term Management Strategy for Hypertension and Obesity This file provides data documentation for the prolonged water-only fasting followed by a whole-plant food diet is a potential long-term management strategy for hyptension and obesity project. Contact Dr. Toshia Myers ([[e-mail]](mailto:[e-mail])) with any questions. This manuscript was published on 11/20/2024: Zeiler, E., Gabriel, S., Ncube, M., Thompson, N., Newmire, D., Scharf, E. L., Goldhamer, A. C., & Myers, T. R. (2024). Prolonged Water-Only Fasting Followed by a Whole-Plant-Food Diet Is a Potential Long-Term Management Strategy for Hypertension and Obesity. Nutrients, 16(22), 3959\. [https://doi.org/10.3390/nu16223959](https://doi.org/10.3390/nu16223959) The tnhtn12m_single_tab_minimal_data.csv data file is the minimal dataset needed to reproduce manuscript findings. NA: Not applicable ## tnhtn1...