Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3‑Kinase δ through a Deconstruction and Regrowth Approach
收藏Figshare2018-12-26 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Discovery_of_Potent_Efficient_and_Selective_Inhibitors_of_Phosphoinositide_3_Kinase_through_a_Deconstruction_and_Regrowth_Approach/7501757
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A deconstruction of previously reported phosphoinositide 3-kinase δ (PI3Kδ) inhibitors and subsequent regrowth led to the identification of a privileged fragment for PI3Kδ, which was exploited to deliver a potent, efficient, and selective lead series with a novel binding mode observed in the PI3Kδ crystal structure.
创建时间：
2018-12-26
