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piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire

ChEBI2015-08-31 更新2026-07-12 收录

转座子调控

piRNA机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-71775 数据链接链接失效反馈

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资源简介：

piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire

应用场景：

创建时间：

2015-08-31

转座子调控

piRNA功能

PIWI-clade Argonaute proteins silence transposon expression in animal gonads. Their target specificity is defined by bound ~23-30nt piRNAs that are processed from single-stranded precursor transcripts

NIAID Data Ecosystem120

Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice

piRNA机制

生殖细胞转座子沉默

Derepression of transposable elements (TEs) in the course of epigenetic reprogramming of the mouse embryonic germline necessitates the existence of a robust defense that is comprised of PIWI/piRNA pat

NIAID Data Ecosystem80

Crystal structure of Zucchini from mouse (mZuc / PLD6 / MitoPLD) bound to tungstate

蛋白质晶体

piRNA机制

Crystal structure of Zucchini from mouse (mZuc / PLD6 / MitoPLD) bound to tungstate Descriptor: Mitochondrial cardiolipin hydrolase, TUNGSTATE(VI)ION, ZINC ION Authors: Ipsaro, J.J, Haase, A.D, Hannon

Protein Data Bank Japan2023-09-13 更新30

Data_Sheet_1_Conserved and Widespread Expression of piRNA-Like Molecules and PIWI-Like Genes Reveal Dual Functions of Transposon Silencing and Gene Regulation in Pinctada fucata (Mollusca).docx

piRNA机制

软体动物表观遗传调控

PIWI proteins and PIWI-interacting RNAs (piRNAs) suppress transposon activity in animals, thus safeguarding the genome from detrimental insertion mutagenesis. Recent studies revealed additional target

NIAID Data Ecosystem100

Zmym2 is essential for methylation of germline genes and active transposons in embryogenesis [RNA-seq]

发育表观遗传学

转座子调控

ZMYM2 is a transcriptional repressor whose role in development is largely unexplored. We found that Zmym2-/- mice show embryonic lethality by E10.5. Molecular characterization of Zmym2-/- embryos reve

NIAID Data Ecosystem50

piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire

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