Data for: High elevation adaptation is associated with functional changes in the immune response of deer mice

Adaptation to high altitude environments shapes whole organism physiology, but effects on the immune system are relatively understudied. These datasets, data processing scripts, and analyses evaluate whether local adaptation to high altitudes in the North American deer mouse (Peromsycus maniculatus) has led to differentiation in and differential function of the immune system. Deer mice derived from low and high altitude populations were bred in a common-garden environment and challenged with lipopolysaccharide (LPS), a component of bacterial cell walls. We collected data on the febrile response (fever) and acute phase response (body mass loss and anorexia) over 12 days following LPS challenge. We also collected data on phenotypic metrics and splenic tissue following an acute challenge with the same LPS dose. Together, these data and analyses demonstrate that low and high-altitude deer mice have diverged in their immune responses to a common challenge in ways that may be consequential fo..., , # Data for: High elevation adaptation is associated with functional changes in the immune response of deer mice

Dataset DOI: [10.5061/dryad.gtht76j0p](https://doi.org/10.5061/dryad.gtht76j0p)

## Description of the data and file structure

Deer mice (*Peromyscus maniculatus*) derived from 2 populations (lowland and highland) were subjected to a bacterial immune challenge (LPS) to elicit an innate immune response. In these mice, we collected body temperatures via PIT-tags to assess the febrile response, tracked metabolic recovery (body weight change and food consumption), analyzed serum corticosterone, and examined differential expression of genes from RNA-seq of the spleen. The effects of LPS were compared to a saline control for these parameters.

### Files and variables

#### File: Cleaned_Temp_Data.csv

**Description:** Temperature data collected from mice. This file has been cleaned using scripts posted previously.

##### Variables

* Trial: Round of experiments (1-4)
* Tag.ID: Uni..., ,