Crystal structure of the human METTL3-METTL14 in complex with compound 4

Crystal structure of the human METTL3-METTL14 in complex with compound 4 Descriptor: 8-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-phenyl]-2-[6-(methylamino)pyrimidin-4-yl]-2,5,8-triazaspiro[3.5]nonan-6-one, ACETATE ION, MAGNESIUM ION, ... Authors: Bedi, R.K, Caflisch, A. Deposit date: 2025-07-01 Release date: 2026-03-18 Last modified: 2026-04-29 Method: X-RAY DIFFRACTION (2.56 Å) Cite: Ligand-Induced Opening of a Cryptic Pocket in METTL14. Acs Bio Med Chem Au, 6, 2026