Ets1 modulates epigentic landscape of key TFH genes in T naïve cells. Ets1 modulates epigentic landscape of key TFH genes in T naïve cells

Ets1 can directly bind key TFH genes, regulating their expression . Loss of Ets1 results in the pre-mature expression of TFH-genes in Non-TFH cells. We wished to analyze if loss of Ets1 correlated with changes in chromatin accessibility especially in TFH gene loci. Overall design: DNA was extracted from splenic CD4+CXCR5+PD-1+ TFH and CD4+CD44-CD62L+ T naïve cells in Ets1 fl/fl and CD4-cre Ets1 fl/fl mice and analyzed by ATAC seq.