首页/数据集/Rictor Plays a Pivotal Role in Maintaining Quiescence as well as Stemness of Leukemia Stem Cells in MLL-Driven Leukemia

Rictor Plays a Pivotal Role in Maintaining Quiescence as well as Stemness of Leukemia Stem Cells in MLL-Driven Leukemia

ChEBI2016-07-19 更新2026-07-12 收录

白血病发病机制

肿瘤靶点研究

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-84505 数据链接链接失效反馈

官方服务：

资源简介：

Rictor Plays a Pivotal Role in Maintaining Quiescence as well as Stemness of Leukemia Stem Cells in MLL-Driven Leukemia

应用场景：

创建时间：

2016-07-19

造血干细胞调控

白血病发病机制

Recurrent inactivating mutations have been identified in various hematological malignancies in the X-linked PHF6 gene. However, it is currently unknown how PHF6 regulates normal hematopoiesis and how

NIAID Data Ecosystem120

Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia [ATAC-seq]

白血病发病机制

表观遗传调控

MGA (Max-gene associated) is a dual-specificity transcription factor that negatively regulates MYC-target genes to inhibit proliferation and promote differentiation. Loss-of-function mutations in MGA

NIAID Data Ecosystem30

Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation

干细胞研究

白血病发病机制

Additional Sex Combs Like 1 (ASXL1) is frequently mutated in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes hematopoietic transformati

NIAID Data Ecosystem10

ChIP-seq BigWig signal tracks for genome-wide chromatin profiling in CD34+ PB-HSPCs and

基因组学分析

白血病发病机制

These bigWig files contain normalized ChIP-seq signal tracks generated from CD34+ PB-HSPCs and in vitro differentiated megakaryocytes and monocytes. The data represent genome-wide binding profiles of

NIAID Data Ecosystem40

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [TargetedCRISPRscreen]

白血病发病机制

CRISPRi筛选

Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe

NIAID Data Ecosystem30

Rictor Plays a Pivotal Role in Maintaining Quiescence as well as Stemness of Leukemia Stem Cells in MLL-Driven Leukemia

资源简介：

相关数据集