Expression data from control and LRF (leukemia/lymphoma related factor)-deficient mouse LT-HSCs

ChEBI2012-10-26 更新2026-07-21 收录

白血病淋巴瘤分子机制

造血干细胞功能

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-41839 数据链接链接失效反馈

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Expression data from control and LRF (leukemia/lymphoma related factor)-deficient mouse LT-HSCs

创建时间：

2012-10-26

Global Gene Expression of hematopoietic stem cells expressing endogenous NrasG12D/G12D, NrasG12D/+, Nras+/+. Mus musculus

造血干细胞功能

肿瘤发生机制

Oncogenic NRAS mutations are frequently identified in human myeloid leukemias. In mice, expression of endogenous oncogenic Nras (NrasG12D/+) in hematopoietic cells leads to expansion of myeloid progen

NIAID Data Ecosystem50

STAT1 is essential for hematopoietic stem cell function and maintains a MHC IIhi stem cell subset that resists myeloablation and neoplastic expansion [LK]

造血干细胞功能

STAT1基因

Adult hematopoietic stem cells (HSCs) are predominantly quiescent and can be activated in response to acute stress such as infection or cytotoxic insults. STAT1 is a pivotal mediator of interferon (I

NIAID Data Ecosystem40

Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets

衰老生物学

造血干细胞功能

Contains the input data used in the analysis of the paper: Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets (Su, Hauenstein, Somuncular et al., Nat

NIAID Data Ecosystem20

The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Mus musculus

骨髓增生异常综合征小鼠模型

造血干细胞功能

Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on

NIAID Data Ecosystem40

Expression and function of PML-RARA in the multipotent hematopoietic progenitor cells of Ctsg-PML-RARA mice

急性早幼粒细胞白血病机制

造血干细胞功能

Because PML-RARA-positive acute promyelocytic leukemia (APL) is a morphologically differentiated leukemia, much speculation has been made about whether its leukemic cell of origin might be committed m

NIAID Data Ecosystem30

Expression data from control and LRF (leukemia/lymphoma related factor)-deficient mouse LT-HSCs

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