Concise Synthesis of Tricyclic Isoindolinones via One-Pot Cascade Multicomponent Sequences

A series of enantiopure tricyclic isoindolinones has been successfully synthesized through a one-pot selective cascade process from furan derivatives. The synthesis is straightforward and gave good overall yields taking into account the concomitant formation of five C−C, C−O, and C−N bonds. The strategy was extended to the preparation of a thiazolidine analogue.