Intestinal Microbiome, CIRS-G Score, and Creatinine Levels as Prognostic Factors for 18-Month Mortality in Long-Living Male Patients Under Multi-Drug Therapy

Multimorbidity and polypharmacy are common in long-living patients and have been linked to alterations in gut microbiota. However, the prognostic relevance of these microbiota changes remains unclear in this population. We hypothesized that clinical parameters and gut microbial profiles are associated with survival outcomes. This exploratory study aimed to investigate the relationships between intestinal microbiota, clinical variables, and 18-month mortality in long-living male patients undergoing multi-drug therapy.