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Clinical drug resistance linked to inter-convertible phenotypic and functional states of tumor-propagating cells in multiple myeloma

ChEBI2012-11-21 更新2026-07-21 收录

多发性骨髓瘤耐药机制

癌细胞可塑性

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MEXP-3772 数据链接链接失效反馈

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资源简介：

Clinical drug resistance linked to inter-convertible phenotypic and functional states of tumor-propagating cells in multiple myeloma

应用场景：

创建时间：

2012-11-21

多发性骨髓瘤耐药机制

S100蛋白家族功能研究

Despite several new therapeutic options, multiple myeloma (MM) patients experience multiple relapses and inevitably become refractory to treatment. Insights into drug resistance mechanisms may lead to

NIAID Data Ecosystem60

NPM1 mediated up – regulation of CXCR4 might drive bortezomib resistance in multiple Myeloma

多发性骨髓瘤耐药机制

NPM1基因

Bortezomib (BTZ) containing regimens induces significant antitumor response in multiple myeloma (MM) and are considered as the first-line treatment. However, resistance is still one of the unsolved pr

Figshare2025-10-25 更新20

A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs [ATAC-seq]. A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs [ATAC-seq]

肺神经内分泌细胞命运决定

癌细胞可塑性

The Notch pathway is a conserved cell-cell communication pathway that controls cell fate decisions. Here we sought to determine how Notch pathway activation inhibits the neuroendocrine cell fate in th

NIAID Data Ecosystem20

ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma [RNA-seq]

多发性骨髓瘤耐药机制

肿瘤转录组学

Immunomodulatory Drugs (IMiDs) are a backbone therapy for multiple myeloma (MM). Despite their efficacy, most patients develop resistance and the mechanism(s) are not fully defined. Here, we show that

NIAID Data Ecosystem40

snATAC-seq data from single cell multiomics (paired snRNA-seq+snATAC-seq) of human colorectal cancer liver metastatic samples

结直肠癌肝转移风险

癌细胞可塑性

These samples are part of a study investigating cancer cell plasticity in colorectal cancer metastasis. Tumour microenvironment cell types and cancer cell states were identified using 10x Genomics Mul

NIAID Data Ecosystem20

Clinical drug resistance linked to inter-convertible phenotypic and functional states of tumor-propagating cells in multiple myeloma

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