Additional file 1 of Quantitative proteomic analysis of HER2 protein expression in PDAC tumors

Additional file 1: Table S1. Demographic and clinical characteristics of the patients. Table S2. The HER2Total, pHER2Y1248, and pHER3Y1289 abundances quantified by RPPA are reported as categorical values of 0, 1, 2, and 3, as well as normalized percentile values ranging from 0-100% relative to the reference population standards. The IHC-based characterizations of HER2Total are reported as quartile-based categorical values of 0, 1, 2, and 3, per standard clinical scoring, for which an IHC score of 3+ or 2+/FISH-positive is clinically defined as HER2-positive. Clinical IHC-based HER2Total testing was not performed for all tumors; those tumors without IHC data are reported as “Not evaluated”. Table S3. Spearman correlations were calculated between the HER2Total and pHER2Y1248 abundances quantified by RPPA each for PDAC and breast cancer tumors, and between the HER2Total abundances quantified by RPPA and standard clinical IHC staining each for PDAC and breast cancer tumors. ND = not done (IHC staining not performed).