Putative lung tumor modifier loci identified by previous genome-wide association studies or by the present study using the WTCHG SNP panel.

aSLT1 to SLT5 loci, reported to affect spontaneous lung tumor incidence in 13 strains [7]; Clas1 to Clas4 loci, reported to affect lung tumor multiplicity in 21 strains [8]. Additional SLT and Clas loci derive from the present study; for each locus region (1 Mb size), the SNP showing the best statistical association is shown.
bSelected SNPs mapping in the reported SLT1 to SLT5 or Clas1 to Clas4 regions were genotyped in all strains for which phenotypes were available (Table 1); the SNPs showing the highest association with the phenotype are shown.
cPosition (in Mb) based on Ensembl release 49.
dThe association between each SNP and lung tumor phenotypes (expressed as log+1 of phenotype value) was tested by t-test. Minus log P values reported in bold type indicate the associations above the statistical threshold obtained by permutation (at α = 0.10 significance level).