Rehabilitative Impact of Exercise Training on Human Skeletal Muscle Transcriptional Programs in Parkinson’s Disease. Rehabilitative Impact of Exercise Training on Human Skeletal Muscle Transcriptional Programs in Parkinson’s Disease

We performed transcriptional profiling to test the hypotheses that a) type I myofiber grouping severity in Parkinson's disease skeletal muscle is linked to distinct gene expression networks and b) high-intensity resistance exercise rehabilitation training influences the skeletal muscle transcriptome in individuals with Parkinson's disease. Overall design: Bulk poly-A RNAseq was performed on skeletal muscle from 12 individuals with Parkinson's Disease, 12 age and sex-matched old adults, and 12 sex-matched young adults. Five of the 12 subjects with Parkinson's disease were also profiled following 16-wk of resistance training.