DVL2 binds phosphorylated WWTR1 (TAZ)

Phosphorylated WWTR1 (TAZ) and DVL interact to form a complex in the cytosol. Thus sequestered, DVL2 is unable to undergo phosphorylation by casein kinase, inhibiting its role in WNT signaling. WWTR1 - DLV interaction thus appears to link the Hippo and WNT signaling processes (Varelas et al. 2010). The stoichiometry of the WWTR1:DVL complex is unknown.

磷酸化的WWTR1（TAZ）与DVL相互作用，在细胞质中形成复合物。因此，被隔离的DVL2无法被酪蛋白激酶磷酸化，从而抑制其在WNT信号传导中的作用。WWTR1-DLV的相互作用似乎将Hippo和WNT信号传导过程联系起来（Varelas等，2010）。然而，WWTR1:DVL复合物的化学计量比尚不明确。