Iridium-Catalyzed Direct C–H Sulfamidation of Aryl Nitrones with Sulfonyl Azides at Room Temperature

Ir­(III)-catalyzed direct C–H
sulfamidation of aryl nitrones
has been developed to synthesize various sulfamidated nitrones in
moderate to excellent yields with excellent regioselectivity and broad
functional group tolerance. This transformation could proceed smoothly
at room temperature with low catalyst loading in the absence of external
oxidants, acids, or bases. Molecular nitrogen was released as the
sole byproduct, thus providing an environmentally benign sulfamidation
process. And this protocol could efficiently apply to synthesize the
substituted benzisoxazoline via one-step transformation from the product.