ACE inhibitor pathway
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The core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by angiotensin converting enzyme. Ang II activates the angiotensin II receptor type 1 to induce aldosterone synthesis, increasing water and salt resorption and potassium excretion in the kidney and increasing blood pressure. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)
此途径的核心机制自一个多世纪前就已阐明，涉及由肾素将血管紧张素原转化为血管紧张素I（Ang I），随后通过血管紧张素转化酶的作用，将其转化为血管紧张素II（Ang II）。Ang II通过激活血管紧张素II受体1型，诱导醛固酮的合成，从而增加肾脏对水和钠的重吸收及钾的排泄，并提高血压。资料来源：PharmGKB（http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway）
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