NetworKIN analysis of BIC VUSs affecting biologically characterized phosphorylation motifs in BRCA1 and BRCA2.

In bold are BRCA1 mutations that directly mutate an experimentally identified phosphorylation site. aThe position and change at the amino acids specified by the missense variant is as reported in the BIC database. bThe nucleotide change conforms to the HGVS nomenclature. cSNP IDs correspond to the dbSNP database [73] SNP identifiers. dFrequency represents the number of times reported in the BIC database. eThe ten-residue long biologically uncharacterized kinase recognition motifs are shown. The biologically uncharacterized Serine (S), and threonine (T) residues shown to be phosphorylated by NetworKIN are underlined.